Many drugs contain primary amino group can be utilized for synthesizing Schiff’s basses with different
uses. A series of Schiff’s bases ( Z1 - Z5 ) have been synthesized using (vanillin) and3,4 diaminopyridine
,procaine , Met form in , 2-arsanilic acid and RhodamineZ1 and Z2 were synthesized using acidic catalyst
while basic catalyst has been used in the synthesis of Z3- Z5 .The characterization was performed using
elemental analysis , FT-IR and proton NMR spectroscopes . The prepared compounds were biologically
evaluated against gram positive and gram negative bacteria. The results showed excellent to moderate
anti-bacterial activity.