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Synthesis and Characterization of New Prodrug Polymers and

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 مهند موسى كريم الحجامي 11/11/2017 06:19:24
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The main concern of modern science is to develop novel drugs and improve present drug’s therapeutic
efficiency. The traditional drug forms such as tablets, injections etc., and their delivery routes such as oral,
intravenous, skin application etc., may have side effects or toxicity in some or the other forms which makes
them inadvisable [1, 2]. The other main problem with traditional drugs are its variable concentration with time;
as a result drug has to be administered repeatedly with high dosage. This variable concentration can be due to a
drug’s physicochemical properties like low in vivo half life, decreased water solubility which in turn causes low
drug availability at desired site [3]. These problems can be avoided mainly by two approaches: one is to design
new drugs with desirable properties; and the other is to use new delivery systems for conventional drugs [4].
As discovering and synthesis new drugs is a difficult process and there is a chance that these drugs can
also have the limitations as those of conventional drugs, the second approach is the main focus of scientific
community [5]. Various drug delivery techniques are being developed from the past few years which will have
potential positive effects on improvement of pharmacokinetic and pharmacodynamic characteristics of drugs
[6]. There are various techniques like alteration of the actual drug or conjugations of the drug to another carrier
molecule. In all these techniques polymer prodrug synthesis has been rapidly growing technique [7].

  • وصف الــ Tags لهذا الموضوع
  • Prodrug, Polymer, Ciprofloxacin, Norfloxacin, Anti bacterial activity, Anti Cancer activity, DNA Cleavage Studies

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